Review on the mechanisms of the effects of coenzyme Q10 supplementation on serum levels of leptin and adiponectin

  • Mahsa Gholami Department of Parasitology and Mycology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Ali Khosrowbeygi Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
Keywords: coenzyme Q10, antioxidant, oxidative stress, adiponectin, leptin


Coenzyme Q10 (CoQ10) is a fat-soluble benzoquinone structurally similar to vitamin K, which acts as an antioxidant in scavenging free radicals and inhibiting lipid and protein oxidation. It has been reported that CoQ10 deficiency is linked to multiple chronic diseases. The current study aimed to review the effects of coenzyme Q10 on serum levels of leptin and adiponectin, their ratio and their role in future treatment strategies. We extended the literature search for all relevant articles published in English from the database, including PubMed, Scopus and Google Scholar, until September 2022. CoQ10 plays a protective role against the release of proinflammatory markers and provides an attractive anti-inflammatory therapeutic for treating some human diseases. It has been shown that there is a positive and negative correlation between CoQ10 and adiponectin and between levels of leptin and CoQ10, respectively. Studies showed that CoQ10 supplementation causes an increase in the value of the adiponectin/leptin ratio. In summary, taking medications such as CoQ10 supplements is recommended as a potential therapeutic target to increase adiponectin levels and modulate the effects of oxidative stress.

How to Cite
Gholami, Mahsa, and Ali Khosrowbeygi. 2023. “Review on the Mechanisms of the Effects of Coenzyme Q10 Supplementation on Serum Levels of Leptin and Adiponectin”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (1), 124-31.