CLOSED LOOP SYSTEMS IN TYPE 1 DIABETES – A DREAM THAT MIGHT SOON COME TRUE?
Since the discovery of “pancreine” by Prof. NC Paulescu in 1921, major progresses have been recorded in the treatment of type 1 diabetes (T1D) subjects. Starting from the first crude animal pancreatic extracts, a long chain of discoveries led to the current age of modern insulin analogs and inhaled insulin. The last 40 years marked the fast evolution of insulin therapy by continuous subcutaneous insulin infusion (CSII) using insulin pumps. The modern miniaturized insulin pumps have dedicated glucose meters with specific algorithms for the calculation of boluses according to the carbohydrate intake and current blood glucose level. Moreover some pumps have incorporated systems for reading data from continuous glucose monitor (CGM) systems.