Peculiarities of behavioral response in rats of different sexes with metabolic syndrome under the conditions of carbacetam administration

Abstract

Metabolic syndrome has become prevalent worldwide. It is a multi-component, progressing condition closely associated with nervous system pathology. Clinical signs of metabolic syndrome are not often clear, which makes diagnostics more difficult and promotes the development of severe, sometimes irreversible consequences. At the same time, GABA is known to play a considerable role in memorization processes and the mechanisms of memory formation. Thus, early diagnostics and timely treatment improve the prognosis of the disease. Therefore, our work aimed to study the peculiarities of behavioral response and memorization processes of female and male rats with metabolic syndrome under the conditions of carbapenem administration as a modulator of GABA receptors. The experiments were conducted on laboratory nonlinear white male and female rats weighing 0.220–0.250 kg. Metabolic syndrome was simulated by keeping the rats on a high-fat diet and giving them free access to fructose solution (100 g/L). Carbacetam was administered intraperitoneally at 5 mg/kg for 14 days. Conclusions. According to the results of “open field” and “CPAR” tests, both males and females with metabolic syndrome decrease their motor, locomotor, learning and emotional activity. Administration of GABA-receptor modulator motor activity promoted increases and inconsiderable changes in the emotional behavior of rats by the number of washings that occur. The results indicate the experimental rats’ behavior modulation due to carbacetam administration. At the same time, effective retention of conditioned passive avoidance reflex to electric painful stimulation in rats receiving carbacetam indicates improved cognitive ability.