SEARCHING THE MISSING LINK BETWEEN ALZHEIMER’S DISEASE AND DIABETES

  • Adina Mitrea
  • Simona Georgiana Popa
  • Cristina Muntean
  • Andreea Soare
  • Laura Trotta
  • Antonio Callea
  • Maria Moța
Keywords: insulin resistance, type 2 diabetes, Alzheimer’s disease, progranulin, adiponectin, leptin

Abstract

Recent studies strongly suggest a significant association between diabetes mellitus and Alzheimer Disease (AD) justifying the term “type 3 diabetes”. Studies show that impairment of glucose metabolism occurs very early in the course of AD, leading to a broad range of consequences, among which the accumulation of amyloid beta (Aβ), which per se induces insulin resistance. Furthermore, adipocytokines, recognised markers of insulin resistance, seem to play a role in the development of AD. As for insulin resistance, when AD is considered, the most studied ones are leptin and adiponectin, but also a recently described adipokine - progranulin. It is our belief that both prospective and transversal studies on subjects with both AD and type 2 diabetes (T2D) may prove the role of adipokines not only in AD, but also in this most somber association.

Published
2013-06-15
How to Cite
Mitrea, Adina, Simona Popa, Cristina Muntean, Andreea Soare, Laura Trotta, Antonio Callea, and Maria Moța. 2013. “SEARCHING THE MISSING LINK BETWEEN ALZHEIMER’S DISEASE AND DIABETES”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 20 (2), 177-81. http://rjdnmd.org/index.php/RJDNMD/article/view/237.
Section
Review Articles