INTERRELATIONS BETWEEN INFLAMMATORY AND OXIDATIVE STRESS BIOMARKERS IN OBESE WOMEN WITH TWO COMPLICATIONS (HYPERTENSION, DIABETES)

Inflammation and oxidative stress in women obesity.

  • Nesrine Karaouzene
  • Hafida Merzouk university of Tlemcen
  • Amel Saidi Merzouk
  • Samira Bouanane
  • Lotfi Loudjedi
  • Sid Ahmed Merzouk
Keywords: Hypertension, inflammation, obesity, oxidative stress, type 2 diabetes mellitus

Abstract

Background and aims : Interaction between oxidative stress and inflammation has not been comprehensively investigated in the association obesity – diabetes - hypertension. Our aim was to investigate interrelations between inflammatory and oxidative stress biomarkers in obese women with two complications (hypertension, type 2 diabetes). Material and Methods: 54 obese without complications, 46 diabetic obese, 48 hypertensive diabetic obese women, and 120 healthy controls were recruited from the department of nuclear medicine (Algeria). Inflammatory and oxidative stress biomarkers were assayed by appropriate methods. Results: Inflammatory markers were significantly higher in all obese groups compared to controls. Elevated pro-oxidants and decreased antioxidant markers were noted in obese women. These alterations were accentuated when obesity was associated with hypertension and diabetes. A positive interrelationship between inflammatory mediators and oxidative status, and a negative one with antioxidants were noted during obesity. Hypertension and diabetes enhanced these correlations. Leptin, C-reactive protein, catalase, superoxide dismutase, ion superoxide, peroxynitrite were found to be the best inflammatory and oxidative stress biomarkers that can predict diabetes and hypertension in obese women. Conclusions: oxidative stress and inflammation were intimately interconnected in women obesity associated with diabetes and hypertension.

Published
2019-06-30
How to Cite
Karaouzene, Nesrine, Hafida Merzouk, Amel Saidi Merzouk, Samira Bouanane, Lotfi Loudjedi, and Sid Ahmed Merzouk. 2019. “INTERRELATIONS BETWEEN INFLAMMATORY AND OXIDATIVE STRESS BIOMARKERS IN OBESE WOMEN WITH TWO COMPLICATIONS (HYPERTENSION, DIABETES)”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (2), 129-43. http://rjdnmd.org/index.php/RJDNMD/article/view/578.
Section
Original Research Articles