The evolutionary profile of celiac disease via the compliance to the gluten-free diet in the western Algerian region
Background and aims: To assess the compliance to the gluten-free diet (GFD) of Algerian patients with celiac disease (CD) and to study the impact of long-term GFD on anthropometric, serological and histological parameters of these patients. Material and method: We conducted a retrospective study on 111 cases of CD patients followed up, from pediatric age until now, at the pediatrics department of the ORAN University Hospital Centre for many years. Two groups were made according to their adherence to the gluten-free diet. Results: The clinical presentation of the disease was typical (84.7%) and atypical (15.3%).. Two groups were selected group A and B for non-compliant diet (39.6%) and compliant diet (60.4%) respectively. There was a significant difference between the current age and the two groups of adherence (p=0.008) and with BMI (p < 10-3). However, we noticed an excellent significant difference between a serology under diet and two groups (p=0.001) also with the grade of histology (p < 10-3). Moreover, a significant reduction of IgA and IgG anti-t-TG in group B (p=0.001). Conclusions: CD in Algeria is still characterized by a heterogeneous clinical symptoms and a good compliance to the GFD is a sign of the path to recovery.