MARKERS OF BONE TURNOVER AND 25-HYDROXY VITAMIN D IN WOMEN WITH TYPE 2 DIABETES AND NEWLY DIAGNOSED OSTEOPOROSIS

Abstract

Background and Aims: The aim of the present study was to evaluate the characteristics of bone turnover markers and 25-hydroxy vitamin D levels in women with type 2 diabetes and recently diagnosed postmenopausal osteoporosis. Material and Methods: We performed a retrospective study that included 80 women with newly diagnosed postmenopausal osteoporosis: 40 women with type 2 diabetes (diabetic group) and 40 women without diabetes (non-diabetic group). For data collection we used the patients database of the National Institute of Endocrinology ”C.I. Parhon”, Bucharest, Romania. Results: Women with type 2 diabetes had significantly reduced levels of osteocalcin and crosslaps than non-diabetic women. In the diabetic group, alkaline phosphatase and 25- hydroxy vitamin D were lower than in non-diabetic women but without statistical significance. There was not statistically significant difference of bone mineral density (BMD) between diabetic and non-diabetic groups. Magnesium was significantly lower in diabetic women compared with non-diabetic women. Conclusions: Our results demonstrated a low bone turnover in type 2 diabetic women and it was shown an insufficiency of 25-hydroxy vitamin D in both studied groups. These findings should be taken into account when screening these patients for diabetes complications.