Does TP53 gene polymorphism increase the risk of obesity and chronic pancreatitis comorbidities in type 2 diabetic patients?

  • Mariya Marushchak I. Horbachevsky Ternopil National Medical University
  • Inna Krynytska
Keywords: type 2 diabetes mellitus, comorbidities, TP53 gene, polymorphism


Background and aims: to establish the prevalence of genotype frequencies for TP53 (rs1042522) alleles in type 2 diabetic patients with comorbid overweight/obesity and chronic pancreatitis (CP). Material and methods: The study involved 34 type 2 diabetic patients and 10 healthy individuals. Genomic DNA was extracted from peripheral blood leukocytes using a commercially available DNA isolation kit. The TP53 gene rs1042522 C>G polymorphism was genotyped using the Taq Man real-time PCR method. Results: We found a significant association between the C/C and C/G genotypes of TP53 rs1042522 SNP polymorphism in type 2 diabetic patients with normal body weight without CP and in type 2 diabetic patients with overweight/obesity. However, no significant difference was found between genotypes С/С, C/G and G/G of rs1042522 SNP in TP53 gene in type 2 diabetic patients with obesity and CP vs control group. Conclusions: The presence of the C allele of TP53 SNP rs1042522 polymorphism in both homozygous and heterozygous states may indicate the increased risk of comorbid obesity development in type 2 diabetic population of Ternopil region, Ukraine. Small number of patients used in this study warrants further research.

How to Cite
Marushchak, Mariya, and Inna Krynytska. 2022. “Does TP53 Gene Polymorphism Increase the Risk of Obesity and Chronic Pancreatitis Comorbidities in Type 2 Diabetic Patients?”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 29 (1), 96-103.