A case report of Guillain-Barre syndrome with demyelinating polyradiculoneuropathy

Abstract

Guillain-Barre syndrome (GBS) is an autoimmune disorder with the most common clinical presentation of neuromuscular paralysis. Here we have reported a rare case of GBS in a 64-year-old patient who presented with chief complaints of generalized body aches and difficulty in walking and sitting for the past five days. Laboratory investigations showed an elevation of protein level in the cerebrospinal fluid (122.1 mg/dl) and CK total (24315 U/L). A nerve conduction study done by sampling from Median, Ulnar, Peroneal, Tibial and Sural nerves was suggestive of asymmetrical severe sensory demyelinating polyradiculoneuropathy more prevalent in the lower limb than in the upper limbs. The patient was admitted and treated with antibiotics, analgesics, muscle relaxants, multivitamins and other supportive measures. Given the progressive worsening of symptoms, intravenous immunoglobulin infusion began, after which the patient’s condition gradually improved.