Metabolic syndrome: Correlation between main hormones and oxidative stress parameters
Background and aims: Pathogenetic aspects of the metabolic syndrome are still the subject of debate due to significant differences in the results of many studies. The aim of the study was to examine the correlation between the levels of ghrelin, leptin, insulin, adiponectin, resistin, metabolic syndrome and oxidative stress parameters in patients with obesity of varying degrees. Material and methods: It was examined 44 patients (59.10 % of women and 40.90 % of men) aged 31 to 79 years with a body mass index ˃30 kg / m2 (main group) and 12 patients (66.67% - women and 33.34% - men) aged 25 to 67 years, with a body mass index ˂25 kg / m2, which made up the control group. Plasma levels of glycated hemoglobin, glycemia, as well as total cholesterol, low and high density lipoproteins, triglycerides, eptin, ghrelin general, adiponectin, oxidized low-density lipoprotein cholesterol, resistin were measured. Results: The analysis confirmed the presence of an imbalance of orexigenic and anorexigenic hormones in obese patients, with a progressive increase in leptin, insulin and decreased levels of ghrelin, adiponectin with increasing obesity, as evidenced by the corresponding correlations. Metabolic syndrome is characterized by excessive accumulation of fat in adipose tissue, which leads to adipocyte hypertrophy, hypoxia, and the development of systemic oxidative stress. Because adipose tissue is responsible for the production of various vasoactive adipokines to modulate vascular function, adipose tissue dysfunction caused by obesity significantly contributes to the pathogenesis of cardiovascular disease. Correction of metabolic parameters and oxidative stress is a potential strategy for the prevention and treatment of cardiovascular disease.