Study of oxidant/antioxidant balance and insulin resistance status in both hypo- and hyperthyroid patients: relationship between thyroid hormones and insulin resistance components

  • El hadjela Derai Department of Molecular and Cell Biology, Laboratory of Molecular Toxicology, Faculty of Nature and Life Sciences, University of Mohammed Seddik Benyahia-Jijel, Jijel, Algeria
  • Leila Bouhafs Department of Molecular and Cell Biology, Laboratory of Molecular Toxicology, Faculty of Nature and Life Sciences, University of Mohammed Seddik Benyahia-Jijel, Jijel, Algeria
  • Dia Eddine Boueb Clinic of Endocrinology and Diabetology, Jijel, Algeria
  • Fatiha Chebchoub Department of Molecular and Cell Biology, Faculty of Nature and Life Sciences, University of Mohammed Seddik Benyahia-Jijel, Jijel, Algeria
  • Samira Boudebaba Department of Molecular and Cell Biology, Faculty of Nature and Life Sciences, University of Mohammed Seddik Benyahia-Jijel, Jijel, Algeria
Keywords: hypothyroidism, hyperthyroidism, insulin resistance, oxidative stress

Abstract

This study aimed to determine changes in the oxidant/antioxidant status and evaluate the relationship between thyroid hormones and components of insulin resistance in dysthyroid patients. Our study was conducted on 30 women, including 10 euthyroid, 10 hypothyroidism and 10 hyperthyroid subjects. Glycemia, insulinemia and homeostasis model assessment insulin resistance index (HOMA-IR), lipids (triglycerides, total cholesterol, HDL and LDL cholesterol), thyroid hormones (TSH, FT3 and FT4), malondialdehyde levels and antioxidant enzymes activities (catalase, superoxide dismutase and glutathione peroxidase activities) were explored. In the hypothyroid state, IR is characterized by normal plasma glucose, hyperinsulinemia, hyperlipidemia and redox status abnormalities compared to the euthyroid group. TSH levels correlated positively with insulin and HOMA-IR, while FT4 correlated positively with HOMA-IR and insulin in a hyperthyroid state. Thyroid dysfunctions were characterized by an imbalance of the oxidant/antioxidant system and associated with insulin resistance components.

Published
2022-09-30
How to Cite
Derai, El hadjela, Leila Bouhafs, Dia Eddine Boueb, Fatiha Chebchoub, and Samira Boudebaba. 2022. “Study of Oxidant/antioxidant Balance and Insulin Resistance Status in Both Hypo- and Hyperthyroid Patients: Relationship Between Thyroid Hormones and Insulin Resistance Components”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 29 (3), 316-22. https://rjdnmd.org/index.php/RJDNMD/article/view/1135.