Laboratory criteria for comorbid course of type 2 diabetes mellitus and thyroid dysfunction

  • Volodymyr Musiienko
  • Ivan Lukasevych
  • Khrystyna Maksiv
  • Iryna Bandas
Keywords: type 2 diabetes mellitus, hypothyroidism, diffuse nontoxic goiter, laboratory data


Background and aims: Diabetes mellitus (DM) rates have reached endemic levels, which is a major challenge for the modern health care system; the vast majority are patients with type 2 diabetes mellitus (T2DM). The presence of other comorbidities drastically affects diabetic patient outcomes, treatment and management options. The aim of our study was to analyze routine laboratory data of type 2 diabetic patients with thyroid dysfunction and search for possible markers of comorbid course of T2DM, hypothyroidism (HT) and diffuse nontoxic goiter (DNG). Material and method: We analyzed 596 medical records of T2DM patients without thyroid dysfunction and with comorbid HT and/or DNG. Results and conclusions: Type 2 diabetic patients with comorbid HT or DNG have significantly higher BMI, increased level of HbA1c and increased ESR compared with patients with T2DM without thyroid dysfunction. The progression of lipid metabolism disorders in patients with comorbid course of t T2DM and HT is characterized by a significant decrease of HDL-C level, as well as an increase of RC and TG levels compared with T2DM only, as well as the comorbidity of type 2 diabetes mellitus and diffuse nontoxic goiter.

How to Cite
Musiienko, Volodymyr, Ivan Lukasevych, Khrystyna Maksiv, and Iryna Bandas. 2022. “Laboratory Criteria for Comorbid Course of Type 2 Diabetes Mellitus and Thyroid Dysfunction”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 29 (2), 228-35.