Optimization of diagnosis in patients with diabetes mellitus and other comorbid pathology in emergency abdominal surgery

Fedir Vasyliovych Grynchuk; Andrii Ihorovych Shurma; Michael Ivanovich Sheremet; Andriy Fedorovych Grynchuk; Volodymyr Volodymyrovych Tarabanchuk; Oksana Yuriyivna Olinik; Oleksandr Volodymyrovych Lazaruk; Yan Viktorovych Gyrla; Oleksandr Vyacheslavovych Bilookyi

Fedir Vasyliovych Grynchuk Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Andrii Ihorovych Shurma Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Michael Ivanovich Sheremet Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Andriy Fedorovych Grynchuk Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Volodymyr Volodymyrovych Tarabanchuk Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Oksana Yuriyivna Olinik Department of Internal Medicine and Infectious Diseases, Bukovinian State Medical University, Chernivtsi, Ukraine
Oleksandr Volodymyrovych Lazaruk Department of Pathology, Bukovinian State Medical University, Chernivtsi, Ukraine
Yan Viktorovych Gyrla Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Oleksandr Vyacheslavovych Bilookyi Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine

Keywords: comorbid pathology, diabetes mellitus, optical density, venous blood plasma, emergency abdominal surgery

Abstract

Our study assessed the possibility of using ODVP determination in PC patients for diagnostic purposes. The study was carried out on 18 healthy donors and 107 patients (51 with CP). Venous blood was collected through a puncture of the ulnar vein and ODVP was measured on an Agilent Cary 100/300 Series UV-Vis spectrophotometer. Donors at the wavelength ƛ=310 nm found the maximum values of ODVP, which reaches 1.9 units. There were no gender differences. ODVP increased and was different, especially with respect to the type of disease. ODVP in patients with AH, AAC, ACC, AEP and CP was higher than in patients without CP. ODVP in patients with AA, SH, AIO and CP were lower than in patients without CP, but it was not significantly lower. ODVP in patients with ANP and CP was lower than in patients without CP, but was still higher (p<0.05) than in donors. In the plasma of healthy donors at a wavelength ƛ=310 nm, there is a maximum value of ODVP, which reaches 1.9 units, while in patients with acute surgical diseases of the abdominal cavity at this wavelength, ODVP is statistically significantly higher than in donors. ODVP in the presence of CP is also statistically significantly greater than in donors. ODVP in the presence of DM is slightly smaller than in other CP but larger than in donors. Preliminary results indicate that the determination of ODVP at wavelength ƛ=310 can be used for diagnosis in emergency abdominal surgery.