The predictors to medication adherence among adults with type 2 diabetes: a meta-analysis

Artha Budi Susila Duarsa; Aris Widiyanto; Santy Irene Putri; Ayu Anulus; Joko Tri Triatmojo; Asruria Sani Fajriah

Artha Budi Susila Duarsa Faculty of Medicine, Universitas Islam Al-Azhar Mataram, Mataram, Indonesia
Aris Widiyanto Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta, Surakarta, Indonesia
Santy Irene Putri Faculty of Health Sciences, Universitas Tribhuwana Tunggadewi Malang, Jawa Timur, Indonesia
Ayu Anulus Faculty of Medicine, Universitas Islam Al-Azhar Mataram, Mataram, Indonesia
Joko Tri Triatmojo Nursing Study Program, Sekolah Tinggi Ilmu Kesehatan Mamba’ul ‘Ulum Surakarta, Surakarta, Indonesia
Asruria Sani Fajriah Midwifery Study Program, Institut Ilmu Kesehatan STRADA Kediri, Jawa Timur, Indonesia

Keywords: diabetes mellitus type 2, medication adherence, predictors

Abstract

This study aimed to investigate predictors of medication adherence among adults with type 2 diabetes. This article was compiled using a systematic review and meta-analysis study conducted by searching for articles from databases in electronic form, including EMBASE, PubMed, and Science Direct. The inclusion criteria for this study were full articles using a cross-sectional study, with the publication year until 2022. The analysis of articles in this study using RevMan 5.3 software. A random-effect model was used when heterogeneity was observed to pool the studies, and the results were reported via adjusted odds ratio and corresponding 95% confidence interval (CI). A total of 5 articles reviewed in the meta-analysis (consisting 4 articles in each variable) showed that respondents with a strong belief in anti-diabetic medicines (AOR=0.53; 95% CI=0.38 to 0.75; p=0.0003) and high knowledge of diabetes mellitus (AOR=0.85; 95% CI=0.79 to 0.93; p=0.0005) had a lower level of non-adherence to anti-diabetic medication. A strong belief in anti-diabetic medicines and a high knowledge of diabetes mellitus can lower non-adherence to anti-diabetic medication.