Effect of vanadium and chromium citrates on lipid composition in the blood of rats with experimental diabetes

Abstract

In clinical endocrinology, diabetes is one of the most important pathologies due to the high, ever-increasing prevalence and frequent development of complications, including dyslipidemia. The aim of the research was to investigate the effect of organic compounds of vanadium and chromium citrates at the dose of 0.5 μg/ml and 0.1 μg/ml on the metabolism of lipids in the blood of rats with alloxan-induced diabetes. The total amount of lipids was determined by weighing dry using a residue gravimetric method. The separation of lipids into classes was carried out by thin-layer chromatography. Lipid profile showed that non-esterified cholesterol, phosphatidylserine, and lysophosphatidylcholine increased, and esterified cholesterol and phosphatidylethanolamine decreased in diabetic rats. The content of phospholipid, non-esterified cholesterol and triacylglycerol decreased. However, the content of monoacylglycerols and diacylglycerols increased in the blood of diabetic rats with a daily diet of vanadium and chromium citrates at the dose of 0.5 μg/ml and 0.1 μg/ml. Changes in phospholipid content were also noted. Our results indicate the normalization of lipid metabolism with the additional introduction of vanadium and chromium citrates to the diet of animals with hyperglycemia. This may indicate that the present compounds may be the progression of diabetes and the risk of deterioration.