A study to find out the correlation between urine microalbumin and serum uric acid levels among type-2 diabetic patients with nephropathy

Abstract

Diabetic nephropathy is one of the most common complications of diabetes mellitus. Early detection of the complication is required for proper effective and timely treatment. This article aims to determine the role of serum uric acid and microalbumin levels in diagnosing diabetic nephropathy. We collected the data from 100 cases with diabetic nephropathy and 100 with diabetes but without nephropathy controls. Fasting plasma glucose, postprandial blood glucose, uric acid, blood urea nitrogen (BUN) and creatinine levels, microalbumin and eGFR levels were assessed in all the subjects. As a result, the independent sample t-test showed a significant difference in the levels of FBS, BUN, creatinine, uric acid and microalbumin levels among cases and controls (p-value<0.05). Pearson correlation showed a significant positive correlation between serum uric acid and microalbumin. ROC curve showed AUC for HbA1c, serum uric acid and microalbumin as 0.814, 0.713 and 0.706, respectively. In conclusion, serum uric acid can be used as a biomarker for the early detection of diabetic nephropathy.