The association between ABO/RH blood groups and type 2 diabetes mellitus in Dhamar Governorate, Yemen

Bushra Samer; Mohammed Al-Haj; Ahlam Al-Muta’a; Mohammed Al-Shawesh; Anwar Othman; Ahmed Obad; Lamees Ali; Lena Al-Hababi; Maha Esahak; Zainb Al-Nomary; Tahani Al-Hefafy; Maria Al-Qetrfi; Ameen Mohammed; Raghda Malek; Haitham Al-Madhagi

Bushra Samer Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Mohammed Al-Haj Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Ahlam Al-Muta’a Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Mohammed Al-Shawesh Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Anwar Othman Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Ahmed Obad Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Lamees Ali Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Lena Al-Hababi Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Maha Esahak Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Zainb Al-Nomary Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Tahani Al-Hefafy
Maria Al-Qetrfi Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Ameen Mohammed Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Raghda Malek Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen
Haitham Al-Madhagi Biochemical Technology Program, Faculty of Applied Sciences, Dhamar University, Dhamar, Yemen

Keywords: ABO, blood groups, Rh factor, type 2 diabetes mellitus, insulin resistance

Abstract

The literature shows that ABO blood groups and demographic characteristics influence susceptibility to type 2 diabetes mellitus (T2DM) and may be used to stem the rising incidence of the disease. However, these associations vary geographically, which necessitates the need to determine the association in every locality. So far, no study has been performed in Dhmar Governorate to look for the association of diabetes mellitus (DM) with blood groups. We studied the association of ABO blood groups with type 2 diabetes mellitus. This study was conducted in Dhamar Governorate from February to May 2022. The study included 332 people, including patients diagnosed with type 2 diabetes and healthy controls. All participants were examined for ABO and Rh by a slide test method. In addition, sociodemographic and clinical data were collected with a semi-structured pretested questionnaire. The questionnaire included clear questions to collect the relevant data. The order of prevalence of diabetes mellitus noted in the blood group types were O, A, B and AB, respectively. The maximum prevalence of type 2 diabetes mellitus was noted with the O+ blood group at 39.5% and the least with the blood group AB- at 0.6%. There was a significant association between A and O blood groups and the risk of developing T2DM. The present work confirms that blood group A is an alarming risk factor for susceptibility to T2DM.