The interaction between ChREBP rs3812316 gene variant and FiberCreme-IMO cookies on triglyceride levels of hyperlipidemic subjects
A high-fiber diet can reduce the triglyceride levels of hyperlipidemic subjects. FiberCreme-IMO is a non-dairy creamer product containing fiber that potentially improves the triglyceride profile. Genetic variants of ChREBP rs3812316 may affect triglyceride response on the consumption of FiberCreme-IMO cookies. This study investigated the effect of FiberCreme-IMO on triglyceride levels and the interaction between FiberCreme-IMO and genotypes of ChREBP rs3812316 on triglyceride levels of hyperlipidemic subjects. Fifty adults with hyperlipidemia were assigned into two groups: one group consumed cookies made from FiberCreme-IMO (n=25), and another consumed control cookies containing coconut milk powder (n=25). Each subject consumed 80 grams of cookies per day for four weeks. Serum triglycerides were measured at baseline and four weeks after treatment. Genotypes of ChREBP rs3812316 were analyzed at the end of the study using PCR-RFLP. FiberCreme-IMO cookies reduced the triglyceride levels compared to control cookies, but the reduction was not statistically significant (p>0.05). There was no significant interaction between FiberCreme-IMO cookies and ChREBP rs3812316 on the triglyceride levels. This study suggests that FiberCreme-IMO ameliorated the triglyceride levels of hyperlipidemic subjects after four weeks of consumption.