Inflammatory marker interleukin-6 in risk stratification of COVID-19 patients

  • Farhana Begum Department of Biochemistry, Chettinad Hospital & Research Institute – Chettinad Academy of Research and Education (CARE), Rajiv Gandhi Salai, Kelambakkam, Tamil Nadu, India
  • Murugavel Murugavel Department of Biochemistry, Chettinad Hospital & Research Institute – Chettinad Academy of Research and Education (CARE), Rajiv Gandhi Salai, Kelambakkam, Tamil Nadu, India
  • Karpagavel Lakshmanan Department of Biochemistry, Chettinad Hospital & Research Institute – Chettinad Academy of Research and Education (CARE), Rajiv Gandhi Salai, Kelambakkam, Tamil Nadu, India
Keywords: Interleukin-6, COVID-19, chemiluminescence assay, inflammatory marker and qRT – PCR

Abstract

The main purpose of this study is to determine the levels of interleukin-6 in COVID-19 patients and see if these inflammatory markers can speculate the extremity of COVID-19 patients. Therefore, previous work on serum ferritin levels in COVID-19 patients has been conducted by the authors as a presumptive observational study [11]. The study’s inclusion criteria comprised 100 individuals who were over the age of 18 and were diagnosed with COVID-19 by real-time quantitative reverse transcriptase polymerase chain reaction method for severe acute respiratory syndrome (SARS-CoV-2). The exclusion criterion was framed according to our previous study [11]. They were bifurcated into the following categories such as: mild to moderate (Group I) and severe to critical (Group II). IL-6 was quantified and evaluated in both groups using the chemiluminescent method [11]. Group I had a mean IL 6 value of 27 pg/ml, while Group II had a value of 126 pg/ml. COVID-19 individuals with elevated IL-6 levels had more indicative predictions, extremity, and serious illness, particularly in group II (P<0.000), and constant in group I, IL-6 levels showed a statistically significant (P<0.000) association with symptomatic indications, severity, and critical illness. Interleukin-6 can be used as a prediction factor for disease severity in the early diagnosis of COVID-19.

Published
2023-12-31
How to Cite
Begum, Farhana, Murugavel Murugavel, and Karpagavel Lakshmanan. 2023. “Inflammatory Marker Interleukin-6 in Risk Stratification of COVID-19 Patients”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (4), 429-31. https://rjdnmd.org/index.php/RJDNMD/article/view/1249.