Effect of fermented milk Lactiplantibacillus pentosus HBUAS53657 on blood glucose, lipid profiles and inflammation in high-fat diet-induced mice

  • Susmiati Susmiati Department of Basic and Fundamental Nursing, Faculty of Nursing, Universitas Andalas, West Sumatra, Indonesia https://orcid.org/0000-0001-6245-6562
  • Najmiatul Fitria Department of Pharmacology and Clinical Pharmacy, Facuty of Farmacy, Universitas Andalas, West Sumatra, Indonesia
  • Ilfa Khairina Department of Basic and Fundamental Nursing, Faculty of Nursing, Universitas Andalas, West Sumatra, Indonesia
  • Huriya Alzahra Department of Department of Animal Product Technology, Faculty of Animal Science, Universitas Andalas, West Sumatra, Indonesia
Keywords: antidiabetic, antidyslipidemia, probiotic

Abstract

Lactobacillus pentosus strains with health-promoting properties, such as immunomodulatory and antiproliferative activities, are potential probiotic strains. L. pentosus HBUAS53657 is one of the most common strains found in dadih (buffalo fermented milk) originating from Tanjung Bonai Lintau Buo Utara. A previous study found that L. pentosus HBUAS53657 had probiotic characteristics. It is necessary to investigate the effect of L. pentosus HBUAS53657 fermented milk probiotics on inflammatory markers in experimental animals. This study is a true experimental design with only a post-test control group. The population consisted of Wistar rats (Rattus norvegicus) n=28 divided into four groups: the control group (ND), the High Fat Diet (HFD) group, the High Fat Diet and L. pentosus HBUAS53657 group 109 CFU/ml (HFDL), and the High Fat Diet and fermented milk with L. pentosus strain HBUAS53657 109 CFU/ml and 20% oranges group (HFDSF). This feeding was done for six weeks (42 days). The research data was processed and statistically analyzed using the Way ANOVA test, followed by the Post hoc test. The results showed that L. pentosus HBUAS53657 fermented milk slowed weight gain in rats given HFDSF by 15.36%, compared to 18.26% in the HFDL group and 24.30% in the HFD group (P<0.01). When compared to the HFD group, the HFDSF and HFDL groups had lower blood glucose, total cholesterol, triglycerides, and LDL (p<0.05, p<0.01, P<0.05). L. pentosus HBUAS53657 reduced the level of serum TNF-α on HFD but not significantly. This demonstrates the protective effect of L. pentosus HBUAS53657 on lipid metabolism disorders in rats fed high-fat rats. L. pentosus HBUAS53657 can reduce HFD-induced proinflammatory cytokines.

Published
2023-12-31
How to Cite
Susmiati, Susmiati, Najmiatul Fitria, Ilfa Khairina, and Huriya Alzahra. 2023. “Effect of Fermented Milk Lactiplantibacillus Pentosus HBUAS53657 on Blood Glucose, Lipid Profiles and Inflammation in High-Fat Diet-Induced Mice”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (4), 440-46. https://rjdnmd.org/index.php/RJDNMD/article/view/1278.