The evaluation of fertility biomarkers in women with endometriosis

Dalal Al-Akabi

Dalal Al-Akabi Department of Health and Medical Techniques, College of Health and Medical Techniques, Southern Technical University, Basrah, Iraq https://orcid.org/0000-0003-2939-3621

Keywords: anti-mullerian hormone, inhibin B, dehydroepiandrosterone, sex hormone binding globulin

Abstract

Endometriosis is a chronic gynecological disease that causes infertility and pain among women of reproductive age, where tissue similar to that of endometrium grows outside the uterus. The current study aims to measure the levels of some fertility-related hormones and their relationship to disease physiology. The study included 90 serum samples divided into 45 women with EMT and 45 healthy women aged between 20 and 41 diagnosed by ultrasound and laparoscopy, and the questionnaire forum obtained all sample information. AMH, inhibin B, DHEA and SHBG were measured by the ELISA method and the results were statistically analyzed SPSS (P<0.05). The current results showed a significant decrease in serum AMH and inhibin B, a non-significant decrease in serum DHEA and SHBG in EMT patients compared to healthy women, a significant decrease in serum inhibin B in patients with advanced stage, and a significant decrease in serum AMH in non-fertile patients compared with fertile patients. In conclusion, fertility issues are recorded in many diagnosed cases of EMT, confirming the obvious imbalance in sex hormone levels due to the presence of uterine tissue in other sites of the body, which affects the hormonal response.