Synergistic antihyperlipidemic effect of alpha lipoic acid with rosuvastatin in high-fat diet-induced hyperlipidemic rats

  • Rawsn Sabri Ali Clinical Laboratory Sciences Department, College of Pharmacy, University of Basrah, Basrah, Iraq
  • Basim Hameed Clinical Laboratory Sciences Department, College of Pharmacy, University of Basrah, Basrah, Iraq
  • Falah Shari Clinical Laboratory Sciences Department, College of Pharmacy, University of Basrah, Basrah, Iraq
Keywords: antihyperlipidemic, rosuvastatin, alpha lipoic acid, high-fat diet

Abstract

The main objective of this study was to assess alpha lipoic acid supplementation with rosuvastatin (lipid-lowering agent) for reducing serum total lipid levels in high-fat diet-hyperlipidemia in rats. For this purpose, twenty- five rats were randomly divided into five groups of normal control (n=5), hyperlipidemic (n=20) groups submitted to the following treatments: A: normal rats; B: hyperlipidemic rats; C: hyperlipidemic rats with rosuvastatin (0.2 mg/kg); D: hyperlipidemic rats with alpha lipoic acid (10 mg/kg); E: hyperlipidemic rats with a combination of rosuvastatin (0.2 mg/kg) plus alpha lipoic acid (10 mg/kg). The lipid profile of these animals was measured at the end of the study (one month). Using alpha lipoic acid alone significantly decreased the lipid profile (p<0.05). The combination of alpha lipoic acid with rosuvastatin is the most effective for reducing serum lipid levels in animals with hyperlipidemia. As a result, alpha lipoic acid supplementation improved the lipid-lowering effect of rosuvastatin.

Published
2023-09-30
How to Cite
Sabri Ali, Rawsn, Basim Hameed, and Falah Shari. 2023. “Synergistic Antihyperlipidemic Effect of Alpha Lipoic Acid With Rosuvastatin in High-Fat Diet-Induced Hyperlipidemic Rats”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (3), 298-305. https://rjdnmd.org/index.php/RJDNMD/article/view/1347.