Synergistic antihyperlipidemic effect of alpha lipoic acid with rosuvastatin in high-fat diet-induced hyperlipidemic rats

Abstract

The main objective of this study was to assess alpha lipoic acid supplementation with rosuvastatin (lipid-lowering agent) for reducing serum total lipid levels in high-fat diet-hyperlipidemia in rats. For this purpose, twenty- five rats were randomly divided into five groups of normal control (n=5), hyperlipidemic (n=20) groups submitted to the following treatments: A: normal rats; B: hyperlipidemic rats; C: hyperlipidemic rats with rosuvastatin (0.2 mg/kg); D: hyperlipidemic rats with alpha lipoic acid (10 mg/kg); E: hyperlipidemic rats with a combination of rosuvastatin (0.2 mg/kg) plus alpha lipoic acid (10 mg/kg). The lipid profile of these animals was measured at the end of the study (one month). Using alpha lipoic acid alone significantly decreased the lipid profile (p<0.05). The combination of alpha lipoic acid with rosuvastatin is the most effective for reducing serum lipid levels in animals with hyperlipidemia. As a result, alpha lipoic acid supplementation improved the lipid-lowering effect of rosuvastatin.