The impact of celiac disease on lipid profile parameters among patients with gallstones disease

Mutasim Mohammed Salih; Zuhair Ghalib ALshaheen; Salah Kadhim Muslim

Mutasim Mohammed Salih Department of Clinical Laboratory Siences, College of Pharmacy, University of Basrah, Basrah, Iraq
Zuhair Ghalib ALshaheen Department of Clinical Laboratory Siences, College of Pharmacy, University of Basrah, Basrah, Iraq
Salah Kadhim Muslim Department of Surgery, College of Medicine, University of Basrah, Basrah, Iraq

Keywords: celiac disease, gallstones disease, cholelithiasis, cholecystokinin, liver function test

Abstract

Celiac disease is an autoimmune disease in genetically susceptible patients upon gluten-rich food intake, and it is thought to have an impact on serum lipid parameters in gallstone patients. The aim is to determine if celiac disease affects serum lipid parameters among patients with gallstone disease. A total of 280 people were included in this prospective study; 134 had gallstone disease, 6 patients had celiac and gallstone disease, and 12 asymptomatic celiac patients were involved. All participants were subjected to immunological investigations (anti-gliadin IgA and IgG; anti-transglutaminase IgA and IgG) via ELISA (Enzyme-Linked Immunosorbent Assay) technique. Biochemical investigations (Lipid profile test) were performed to check serum lipid parameter fluctuations. The gallstones disease and active celiac disease case’s mean age was 41.01 years. Six patients revealed a positive ultrasonography exam for gallstones and a positive immunological test, including anti-gliadin IgA, IgG, and anti-transglutaminase IgA (greater than 10 U/ml). The asymptomatic or silent celiac disease group comprised 12 healthy persons with seropositive immunological results and still with silent symptoms of celiac disease with positive anti-gliadin IgA and IgG only (greater than 10 U/ml). Furthermore, the present research revealed that these two diseases substantially or relatively significantly influenced total cholesterol, triglyceride, LDL, and HDL. Active celiac disease influences serum lipid parameters due to interference with intestinal absorption via intestinal dysmotility and affecting neuropeptides via villi atrophy and crypt hyperplasia. Serum lipids disturbance and biliary cholesterol supersaturation due to intestinal absorption defect in active celiac patients make together to gallstones formation.