Does omeprazole cause functional hypoparathyroidism?
Abstract
Proton pump inhibitors are widely used worldwide and are misused classes of drugs, especially in developing countries. Several case reports, case series, and review studies suggest proton pump inhibitors may cause hypomagnesemia hypoparathyroidism. Therefore, the goal of this case-control study is to determine whether there is a link between omeprazole and functional hypoparathyroidism, and this case-control study is the first study on animal models regarding this project. Twenty mature male rabbits were randomly divided into two groups (10 rabbits/group); Group 1 – the control group, was given distilled water (1ml/kg/day for 45 days) via intraperitoneal (I/P) injection and Group 2 – treated with omeprazole (PPI) (1 ml/kg/day for 45 days) I/P injection to induce hypoparathyroidism. The serum used in the PTH and electrolyte studies was obtained from blood samples taken through cardiac puncture. The results show a significant decrease in PTH, Mg2+ and Ca2+ concentration in the treated group compared to the control group. Omeprazole (PPI) induced hypomagnesemia, a potential cause for functional hypoparathyroidism.