Unveiling the atherogenic lipoprotein particle: A case-control study

  • Jaya Janani Department of Biochemistry, Chettinad Hospital and Research Institute, Chettinad Academy of Research & Education, Kelambakkam, Tamil Nadu, India
  • Karpagavel lakshmanan Department of Biochemistry, Chettinad Hospital and Research Institute, Chettinad Academy of Research & Education, Kelambakkam, Tamil Nadu, India
  • Santhini Gopalakrishnan Department of Biochemistry, Chettinad Hospital and Research Institute, Chettinad Academy of Research & Education, Kelambakkam, Tamil Nadu, India
Keywords: troponin I, coronary artery diseases, non-high-density lipoprotein, low-density lipoprotein, total cholesterol

Abstract

One of the leading causes of death and morbidity in the globe is cardiovascular disease (CAD). According to the WHO statistics from the year, 17.9 million individuals die worldwide every year from cardiovascular diseases. One of the simplest alternatives to computed LDL levels is to make use of non-HDL lipoprotein. Comparing non-HDL cholesterol to LDL cholesterol has shown that multiple research studies have demonstrated non-HDL cholesterol’s superior ability to identify risks for CAD. In order to compare and contrast LDL and non-HDL cholesterol levels in individuals with CAD, the present investigation will compare and contrast these two measurements. Fifty healthy people between the ages of thirty and seventy-five were included in the study as controls, whereas 130 patients with CAD diagnoses were included as cases. The study was conducted among 180 patients who were diagnosed with cardiovascular disease. The positive relationship between non-HDL-cholesterol and LDL cholesterol levels is seen by the Pearson correlation. Using non-HDL cholesterol, an independent T-test yields a positive result of <0.001. The study’s conclusion is that non-HDL cholesterol yields results that are similar to Friedwald’s well-established LDL-C. Non-HDL-C can be used as a marker for CAD deduction and also for diagnostic and therapeutic markers for CAD.

Published
2023-12-31
How to Cite
Janani, Jaya, Karpagavel lakshmanan, and Santhini Gopalakrishnan. 2023. “Unveiling the Atherogenic Lipoprotein Particle: A Case-Control Study”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (4), 398-402. https://rjdnmd.org/index.php/RJDNMD/article/view/1384.