A comparison between the effectiveness of quercetin and glibenclamide on β-cells of male mice under oxidative stress

  • Maryam Bashiri Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Akram Ahangarpour Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Keywords: quercetin, insulin secretion, malondialdehyde, oxidative stress, glycemic conditions, total antioxidant capacity


Low levels of antioxidants in Langerhans’ islets can lead to oxidative stress and damage to beta cells. Many of the symptoms of diabetes may occur as a natural response of the human body to defects in reactive oxygen species (ROS). Many commercially available drugs, such as glibenclamide, are now prescribed to increase insulin secretion. Available studies show that long-term use of glibenclamide as a drug may increase inflammatory factors in β-cells and insulin secretion, as well as underlying diseases due to toxic, mutagenic and carcinogenic effects. This paper presents a comparative study analyzing the detailed effects of glibenclamide versus quercetin (QE), an antioxidant with free radical scavenging activity and minimal negative side effects. In this experimental study, islets were divided into three groups, including control, treatment and comparison, isolated and divided to investigate the proposed drugs’ effects based on the malondialdehyde (MDA) biomarkers, insulin secretion and total antioxidant capacity (TAC). The results of the study show that a high concentration of QE significantly improves insulin secretion in β-cells. In addition, QE has beneficial effects, including decreasing MDA levels and increasing TAC. In conclusion, quercetin can be used in conjunction with more conventional therapies, such as glibenclamide, to reduce oxidative stress and maintain beta-cell functionality for insulin secretion in diabetic patients.

How to Cite
Bashiri, Maryam, and Akram Ahangarpour. 2024. “A Comparison Between the Effectiveness of Quercetin and Glibenclamide on β-Cells of Male Mice under Oxidative Stress”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (2), 126-32. https://rjdnmd.org/index.php/RJDNMD/article/view/1411.