Hypo-glycaemic and hypo-lipidemic effects of citrus aurantifolia (lime) juice in alloxan-induced diabetic rats

  • Ugomma Agwu Ude Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria
  • Michael Erem Kalu Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria
  • Toochukwu John Nwokpor Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria
  • Enyioma Agwu Ude Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
  • Doris Amaka Onweh Department of Laboratory Science, Alex Ekueme University Teaching Hospital, Abakaliki, Nigeria
  • Victor Udoh Usanga Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria
  • Rosemary Ogbonnie Oti-Wilberforce Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria
Keywords: diabetes, dyslipidemia, citrus aurantifolia, hypoglycaemic, hypo-lipidemic

Abstract

Diabetic dyslipidemia causes cardiovascular-related death. Due to the complexity of this disorder, management may be complicated. We evaluated the effects of Citrus aurantifolia juice plasma glucose and lipids on diabetic Wister rats. Twenty-eight female rats were grouped into four of seven rats per group: group I (control), group II (non-diabetic rats treated with lime juice), group III (diabetic rat treated with lime juice) and group IV (diabetic rats not treated with lime juice). Diabetes was induced after an overnight fast by intraperitoneal injection of 120 mg/kg alloxan dissolved in 0.9v/v normal saline. The animals of groups I and IV were given daily treatment of 5 ml distilled water, while groups II and III were administered 5 ml lime juice for seven days. The plasma glucose and lipids were determined using the spectrophotometric method. Pre-lime treatment, glucose, total cholesterol (T. Chol), triglycerides (TG), and low-density lipoprotein (LDL) were significantly higher in diabetic rats compared to non-diabetic rats (p=0.000, 0.010, 0.002 and 0.012) while high-density lipoprotein (HDL) (p=0.008) was lower. Post-lime treatment, there was no significant difference in the concentrations of glucose, T. Chol, TG, HDL and LDL of group III compared to group I rats (p=0.010, 0.643, 0.653, 0.616 and 0.429, respectively). Administration of lime juice may be able to control glycaemic and dyslipidaemia states. We suggest that its application in the management of diabetes and its associated dyslipidaemia be explored.

Published
2024-06-30
How to Cite
Ude, Ugomma, Michael Kalu, Toochukwu Nwokpor, Enyioma Ude, Doris Onweh, Victor Usanga, and Rosemary Oti-Wilberforce. 2024. “Hypo-Glycaemic and Hypo-Lipidemic Effects of Citrus Aurantifolia (lime) Juice in Alloxan-Induced Diabetic Rats”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (2), 176-83. https://rjdnmd.org/index.php/RJDNMD/article/view/1427.