The combined effect of magnesium and chromium citrates on the blood plasma lipid profile in rats under the conditions of alloxan-induced diabetes mellitus

Keywords: diabetes mellitus, magnesium citrate, chromium citrate, lipids


The aim was to study the combined effect of magnesium and chromium citrate on the content and profile of lipids in the blood plasma of rats under alloxan-induced diabetes mellitus (DM) to develop new approaches to correcting metabolic disorders. Four groups of rats (control and three experimental, five male Wistar rats per group) included negative control (CG, no DM), positive DM control (EG1) and two treatments – DM rats fed with combined supplemental magnesium and chromium (EG2 and EG3) daily for 30 consecutive days. Alloxan-induced diabetes (EG1, EG2, EG3 groups) was inflicted on day 21 after dietary supplementation started, and all animals were sacrificed on day 30. The blood samples were analyzed for total lipids, phospholipids, cholesterol, cholesterol esters, di- and tri-acyl glycerols, and free fatty acids. The content of both total blood lipids and their certain classes increased in DM rats. In particular, the increase in cholesterol was due to the oxidative stress caused by pancreatitis, where the intensive oxidation of monoacylglycerols and diacylglycerols occurred. The combined use of magnesium and chromium citrates has led to a partial normalization of lipid content indicators. The prophylactic combined magnesium and chromium use contributed to a decrease in total lipids’ content and the percentage content of phospholipids, cholesterol, diacylglycerol and free fatty acids in the blood plasma under alloxan-induced DM.

How to Cite
Skobeieva, Olena, Iryna Bandas, Liliya Palytsya, Alla Mudra, and Oleksandr Tokarskyy. 2024. “The Combined Effect of Magnesium and Chromium Citrates on the Blood Plasma Lipid Profile in Rats under the Conditions of Alloxan-Induced Diabetes Mellitus”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (2), 204-8.