The influence of Atherophyton on the development of low-grade inflammation in experimental metabolic syndrome in Syrian golden hamsters

  • Kateryna Kalko Department of Pharmacology and Drug Technology, I. Mechnikov Odesa National University, Odesa, Ukraine
  • Maksym Mirzebasov Department of Biology, Histology, Pathomorphology and Forensic Medicine, State establishment Luhansk State Medical University, Rivne, Ukraine
  • Serhii Smirnov Department of Biology, Histology, Pathomorphology and Forensic Medicine, State establishment Luhansk State Medical University, Rivne, Ukraine
  • Iryna Borisyuk Department of General and Clinical Pharmacology, International Humanitarian University, Odesa, Ukraine
  • Dmytro Semeniv Department of Commodity Science and Pharmacy, State University of Trade and Economics, Kyiv, Ukraine
  • Yuliana Bukataru Department of Physiology Ya. D. Kirshenblat, Bukovinian State Medical University, Chernivtsi, Ukraine
  • Olga Sadovnyk Department of Biology, Histology, Pathomorphology and Forensic Medicine, State establishment Luhansk State Medical University, Rivne, Ukraine
Keywords: phytotherapy, cryotechnology, experimental metabolic syndrome, low-grade inflammation, atherophyton

Abstract

The study aimed to investigate the effect of the dietary supplement (DS) Atherophyton on the development of low-grade inflammation by assessing the effect of such cytokines against the background of experimental metabolic syndrome in Syrian golden hamsters. The experimental metabolic syndrome (EMS) in Syrian golden hamsters was induced by keeping the animals for 24 days on a diet enriched with fructose (60% of the total daily diet with complete replacement of drinking with a 10% fructose solution). According to our experimental study, in the conditions of EMS, the leading role in the pathogenesis of which is associated with the development of oxidative stress and subsequent activation of chronic subcellular inflammation, the use of Atherophyton contributed to the suppression of low-grade inflammation, as indicated by a decrease in cytokine levels: IL-1β, IL-6, TNF-α by 1.5 (p<0.05), 1.8 (p<0.05) and 1.7 (p<0.05) times, respectively, which in turn is due to the ability of biologically active substances of medicinal plant materials included in Atherophyton to affect the etiopathogenetic component EMS development and, accordingly, the chronic sub-inflammatory process. DS Atherophyton suppresses the development of low-grade inflammation against the background of EMS in Syrian golden hamsters.

Published
2024-12-16
How to Cite
Kalko, Kateryna, Maksym Mirzebasov, Serhii Smirnov, Iryna Borisyuk, Dmytro Semeniv, Yuliana Bukataru, and Olga Sadovnyk. 2024. “The Influence of Atherophyton on the Development of Low-Grade Inflammation in Experimental Metabolic Syndrome in Syrian Golden Hamsters”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (4), 454-58. https://rjdnmd.org/index.php/RJDNMD/article/view/1663.