Study of the vacuum therapy influence on the wound process in patients with diabetic foot syndrome
Abstract
An open, observational, multicenter, retrospective, randomized, controlled, comparative study of patients in the main and control groups of patients was carried out. Patients were assigned using a table of random numbers. The mixed form of the lesion was not isolated separately, and the patients of this group were divided between neuropathic (NF) and ischemic (IF) forms, respectively, with the peripheral hemodynamics rate. The participants were also divided into patients with acute and chronic wounds. In patients with NF SDS, the formation of healthy granulation tissue began at (4.61±0.96) days, and before (6.43±0.48), the wound surfaces were ready for plastic closure by one of the methods of plastic surgery (imposition of secondary sutures, autodermoplasty). In the control group, plastic wound closure was possible only from (9.42±1.46) days (p<0.05).In patients with IF SDS, the formation of granulation tissue began on (6.53±1.14) days (p<0.02), and the wounds were ready for plastic closure on (8.76±1.25) days (control group – 12.48±1.94 days) (p<0.05). This, in turn, allows to be prepared in a shorter time the wound for closure using one of the methods of plastic surgery or to create favorable conditions for its independent epithelialization. Vacuum therapy can be used in the local treatment of acute and chronic wounds in patients with different pathogenetic forms of DFS and a positive effect is highly expected. It allows the stabilization of the course of the wound process, improves local microcirculation, and stimulates regenerative processes in the tissue.