Study of level of netrin-1 in serum of patients with type 2 diabetic nephropathy

  • Mahmoud Mohamed Naiem Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
  • Khaled Elsayed Elhadidy Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
  • Hanan Hosni Moawad Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
  • Ahmed Moheyeldien Hamed Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
  • Mohamed Ragab Ahmed Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
Keywords: diabetes mellitus, diabetic nephropathy, serum netrin-1, albuminuria

Abstract

Diabetic nephropathy is among the devastating outcomes of diabetes. An essential part of slowing its development is early detection. The goal was to determine the impact of netrin-1 on microalbuminuria and early detection of nephropathy type 2 DM. This trial was conducted on 120 patients divided equally into four groups: group (1) Healthy normal persons; group (2) patients with type 2 DM without albuminuria (albumin/creatinine ratio <30 mg/gm), group (3) patients with type 2 DM with microalbuminuria (albumin creatinine ratio 30–299 mg/gm), and group (4) patients with type 2 DM with overt proteinuria (albumin creatinine ratio ≥300 mg/gm). All participants were subjected to complete history taking, full clinical examination, routine labs, and Netrin-1 level. The highest level of Netrin-1 was found in group 4 (56.2±20.5), followed by group 3 (43.2±22.4), group 2 (36±13.4), and group 1 (33.2±10.8) (P-value <0.001). In addition, there was a significantly higher Netrin-1 level in diabetic nephropathy patients (49.7±22.3) than in patients without nephropathy (34.6±12.1) (P-value <0.001). Plasma netrin-1 level is significantly elevated in patients with diabetic nephropathy, whether micro or macro proteinuria, and there is a future hope for the possibility of using netrin 1 as an early predictor for the diagnosis of diabetic nephropathy.

Published
2024-12-16
How to Cite
Naiem, Mahmoud, Khaled Elhadidy, Hanan Moawad, Ahmed Hamed, and Mohamed Ahmed. 2024. “Study of Level of Netrin-1 in Serum of Patients With Type 2 Diabetic Nephropathy”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (4), 363-70. https://rjdnmd.org/index.php/RJDNMD/article/view/1768.