PROINSULIN LEVEL AS A PREDICTOR OF METABOLIC SYNDROME IN THE ROMANIAN POPULATION

  • Simona Ateia
  • Emilia Rusu
  • Shadia Ateia
  • Vasilică Cristescu
  • Georgiana Enache
  • Adrian Costache
  • Gabriela Radulian
  • Dan Mircea Cheța
Keywords: metabolic syndrome, C-peptide, proinsulin, proinsulin to insulin ratio, proinsulin to C-peptide ratio

Abstract

Background and Aims: The aim of the present study was to determine discriminating values of proinsulin (FPP), proinsulin to insulin ratio (PIR), proinsulin to C-peptide ratio (PCPR) and Homeostasis model of assessment of insulin resistance (HOMA-IR) for the metabolic syndrome (MetS) as well as discovering sex-specific cutoff points of these parameters in the Romanian population. Material and Methods: We analyzed data from 224 patients. Circulating levels of fasting plasma glucose (FPG), fasting plasma insulin (FPI), FPP, fasting plasma C-peptide, HbA1c, and lipid profile were measured. Results: Among the 224 patients (87 males) MetS was diagnosed in 97 patients (43.3%) according to International Diabetes Federation (IDF) criteria. After stratification by gender, 43 men (49.4%) and 54 women (39.4%) had MetS. There were statistically significant differences between sexes for body mass index (BMI), % body fat, FPG, FPP, PIR, PCPR (all p<0.05). On multivariate logistic regression analysis, only age, BMI, FPP, and HOMA-IR were the independent factors associated with the presence of MetS. Conclusions: The present study showed that FPP and HOMA-IR were the best predictors for MetS in this sample of the Romanian population. Our results suggest that, regardless of gender, HOMA-IR and FPP could be the preferred parameters for predicting MetS.

Published
2013-12-15
How to Cite
Ateia, Simona, Emilia Rusu, Shadia Ateia, Vasilică Cristescu, Georgiana Enache, Adrian Costache, Gabriela Radulian, and Dan Cheța. 2013. “PROINSULIN LEVEL AS A PREDICTOR OF METABOLIC SYNDROME IN THE ROMANIAN POPULATION”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 20 (4), 279-387. https://rjdnmd.org/index.php/RJDNMD/article/view/206.
Section
Original Research Articles