OBESITY INFLUENCE ON INSULIN ACTIVITY AND RESTING METABOLIC RATE IN TYPE 2 DIABETES

  • Rodica Dorors
  • Daniela Lixandru
  • Laura Petcu
  • Ariana Picu
  • Manuela Mitu
  • Janeta Tudosoiu
  • Constantin Ionescu-Tîrgoviste
Keywords: resting metabolic rate, type 2 diabetes, insulin resistance, proinsulin, adipocytokines, HOMA

Abstract

Background and Aims. Diabetes mellitus and obesity modify the resting metabolic rate (RMR) in opposite directions. This study aimed to evaluate the relationship between RMR, insulin activity and adipocytokines in type 2 diabetes patients with associated obesity. Material and Method. Anthropometric and biochemical measurements, bioimpedance body composition, C peptide, insulin, proinsulin, adiponectin, leptin, indirect calorimetry measured RMR were determined in 306 (53% male, 54.9% obese) diabetic patients. Results. RMR, C peptide, insulin, proinsulin, Homeostasis Model Assessment (HOMA) IR, HOMA %B, leptin increased and adiponectin decreased with body mass index (BMI). BMI had a statistical significant higher effect size on fat mass (FM), leptin (0.652-0.339 eta squared), moderate positive effect size on fat-free mass (FFM), insulin, C peptide, RMR, HOMA %B (0.228 - 0.155 eta squared) and lower effect size on HOMA IR, adiponectin, proinsulin-to-adiponectin ratio, proinsulin (0.098-0.062 eta squared). RMR had positive correlations with FFM (r=0.633), BMI (r=0.300), proinsulin-to-adiponectin ratio (r=0.218), HOMA1-IR (r=0.176), proinsulin (r=0.151), insulin (r=0.144), fasting plasma glucose (r=0.132), fat mass (r= 0.131), triglycerides (r = 0.119), proinsulin-to-insulin ratio (r= 0.117) and negative with age (r=-0.368), HDL cholesterol (r=-0.284), adiponectin(r=-0.282) and leptin (r=-0.178). Conclusions RMR was correlated with HOMA IR and insulin resistance biomarkers, but not with HOMA %B and C peptide.

Published
2016-12-15
How to Cite
Dorors, Rodica, Daniela Lixandru, Laura Petcu, Ariana Picu, Manuela Mitu, Janeta Tudosoiu, and Constantin Ionescu-Tîrgoviste. 2016. “OBESITY INFLUENCE ON INSULIN ACTIVITY AND RESTING METABOLIC RATE IN TYPE 2 DIABETES”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 23 (4), 377-86. https://rjdnmd.org/index.php/RJDNMD/article/view/71.
Section
Original Research Articles