Decrease of plasma TNF-α and CRP levels in response to postexhaust resistance training and vitamin D supplementation in overweight healthy women

Exercise and vitamin D affect inflammation

  • Narges Kallantar
  • Hoseyn Fatolahi Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran


The purpose of this study was to investigate the simultaneous effect of resistance training and vitamin D supplementation on plasma CRP and TNF-α levels in overweight healthy women. The participants were randomly divided into four groups including: (1) placebo, (2) resistance training (RT), (3) vitamin D, and (4) RT + vitamin D. Interventions were performed for 8 weeks (3 days per week), consisting of resistance training protocol (60% 1-RM) and taking vitamin D (1000 IU per day). Fasting blood samples were collected 48 hours before and after the interventions. A significant decrease in CRP was reported among the studied groups (p=0.001, F=11.4). These changes showed a difference between RT + vitamin D compared to other groups. The CRP values ​​of the RT and vitamin D groups were also significantly lower than the placebo group (P = 0.03). TNF-α was significantly decreased among the studied groups (p = 0.003, F = 5.4). These changes showed a difference between the RT + vitamin D group compared to other groups. TNF-α was significantly lower in the RT and vitamin D groups than in the placebo group (P = 0.03). The findings of this study confirm that adaptation to resistance training, if combined with vitamin D intake, has significant effects on decreasing inflammatory biomarkers at rest. In addition, TNF-α alteration appears to be less effective than resistance training, which may be due to eccentric contractions caused by resistance training.

How to Cite
Kallantar, Narges, and Hoseyn Fatolahi. 2020. “Decrease of Plasma TNF-α and CRP Levels in Response to Postexhaust Resistance Training and Vitamin D Supplementation in Overweight Healthy Women”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 27 (4), 349-56.