Metabolic changes of lipids in patient with subclinical hypothyroidism
Background and Aims: the effect of subclinical hypothyroidism on the dynamics of lipid spectrum during lipid-tolerance test was studied. Subclinical hypothyroidism (SH) is the earliest thyroid dysfunction and is the most common. However, data on the presence of dyslipidemia in subclinical hypothyroidism are controversial. The aim of this study was the early detection of lipid metabolism disorders in patients with subclinical hypothyroidism on the basis of lipid-tolerance testing. Materials and Methods: the study involved 96 people. The main group included 37 patients with subclinical hypothyroidism, but seven of them had fasting hypercholesterolemia, dyslipidemia, and they were excluded from further study. Thus, 30 patients with SH formed the main group 1. Two comparison groups were presented by 59 comparisons by main characteristics (age, sex, exclusion criteria) of individuals without thyroid pathology (group 2) - 30 people, and with overt hypothyroidism (group 3) - 29 people. An oral fat tolerance test was used to evaluate postprandial lipemia. Results and Conclusions: As a result of the study, data were obtained according to which fat load stimulated the development of different levels of postprandial hyperlipidemia, depending on the thyroid status of patients. Patients with subclinical hypothyroidism had postprandial hypertriglyceridemia, which was combined
with an increase in low-density lipoprotein levels and a decrease in high-density lipoprotein levels. The proposed method allows the detection of early disorders of lipid metabolism in patients with subclinical hypothyroidism.