Peculiarities of carbacetam effect on the processes of fibrinolysis and proteolysis in the brain of rats with neurodegeneration induced by type 2 diabetes mellitus
Introduction: Diabetic neurodegeneration is formed with underlying type 2 diabetes mellitus which is an independent factor promoting development of cognitive disorders. Considering an important role of GABA receptors in the development of neurodegenerative processes, the issue concerning Carbacetam effect produced on proteolytic and fibrinolytic mechanisms of the cerebral cortex and hippocampus with experimental simulation of type 2 diabetes mellitus has become of a certain interest. Material and Methods: Type 2 diabetes mellitus was simulated by streptozotocin in the dose of 30 mg/kg injected through the peritoneum of rats kept during 30 days on a high-fat diet with a free access to fructose solution. Results: Under conditions of pathological process development the activity of the main groups of proteolytic enzymes intensify in the cerebral cortex and hippocampus. Carbacetam administration to rats with diabetes mellitus promotes reduction of proteolysis processes which might be associated with pharmacodynamics of the drug. Conclusions: The data obtained experimentally substantiate reasonability of pathogenic correction by means of Carbacetam in case of disorders of proteolytic and fibrinolytic systems activity in the cerebral cortex and hippocampus induced by type 2 diabetes mellitus.