Cytokine profile and C-reactive protein level in patients with ischemic heart disease on the background of metabolic syndrome
Background and aims: The work aimed to study the levels of interleukins 1β, 6, 18, and C-reactive protein in the blood serum of patients with ischemic heart disease.
Material and method: Clinical and laboratory examination of 120 persons from verified ischemic heart disease (IHD) was carried out, of which 60 patients with IHD without metabolic syndrome (group 1) and 60 patients with metabolic syndrome (59 men, 1 woman) - group 2. Age of patients 55±2 yrs. The presence of metabolic syndrome was assessed based on the level of triacylglycerols. The obtained laboratory values were compared with the control group, which included 30 healthy individuals. All study subjects were tested for serum levels of IL-1β, IL-6, IL-18, and C-reactive protein (CRP). Conclusions: It was found that metabolic syndrome in patients with coronary artery disease acts as a trigger for the synthesis of several pro-inflammatory cytokines. Statistically significant increase in IL-1β (1.5 times), IL-6 (8.3 times), IL-18 (1.4 times), and CRP (1.3 times) in group 2 compared to group 1 of patients indicates the presence of an inflammatory process. Determination of the cytokine status of IHD patients can be a biomarker for the development of an inflammatory response.