COPD as metabolic pathology: problem of common oxidative stress, endotoxicities and neurotoxicity

  • Olena Lykholat Department of Psychology, University of Customs and Finance, Dnipro, Ukraine
  • Olena Pavlenko Department of Internal Medicine No. 1, Dnipro State Medical University, Dnipro, Ukraine
Keywords: COPD, metabolic syndrome, oxidative stress, endotoxicosis, neurotoxic effects


Chronic obstructive pulmonary disease (COPD) is an often severely disabling chronic lung disease with a high prevalence of over 250 million cases worldwide. Metabolic syndrome is a comorbidity of COPD and increases medical costs. Interrelationships between metabolic syndrome and early COPD remain unclear. The aim of the presented work was to study the relationship between the development of oxidative stress, endotoxicities and neurotoxicity as a manifestation of a violation of the general metabolic state in patients with COPD. Biochemical, immunohistochemical methods, an electrophysiological examination (encephalography, computer electroencephalogram (EEG) with the analysis of visual evoked potentials) and statistical analysis were used. Thus, a comparison of the obtained data indicates that the development of bronchopulmonary disease’s neurotoxic effect exceeds the general toxic. Certain disorders of the nervous system lead to disorders of integrative signaling systems, which affect the functioning of the lungs and the development of general systemic metabolic pathology. Systemic inflammation promotes the manifestation of metabolic abnormalities and other extra-pulmonary comorbidities that are interconnected in nature. Future progress needs to focus on molecular mechanisms that drive the heterogeneity of COPD disease progression.

How to Cite
Lykholat, Olena, and Olena Pavlenko. 2023. “COPD As Metabolic Pathology: Problem of Common Oxidative Stress, Endotoxicities and Neurotoxicity”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 30 (3), 316-23.