The Effect of Antidiabetic Drugs on the Musculoskeletal System in Women

  • Alina Urbanovych Prof
  • Oksana Kryvko
Keywords: osteoporosis, insulin, DPP-4 inhibitors, SGLT2, thiazolidinediones, metformine


Diabetes mellitus (DM) is a chronic endocrine disorder caused by absolute or relative lack of insulin, which subsequently leads to hormonal and metabolic changes in the body. Since patients receive continuous long-term antidiabetic treatment, there was a chance to analyse the effect of antidiabetic drugs on bone tissue in type 2 DM patients. The results of the studies indicate that bone metabolism is the most adversely affected by treatment with thiazolidinediones and canagliflozin from the group Sodium-glucose co-transporter-2 inhibitors, while Dipeptidyl Peptidase-4 Inhibitors and Insulin have a positive effect on it, and, finally, Glucagon-like peptide-1, Biguanides and Sulfonylureas have rather a slight impact on the bone tissue.

How to Cite
Urbanovych, Alina, and Oksana Kryvko. 2021. “The Effect of Antidiabetic Drugs on the Musculoskeletal System in Women”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 28 (2), 223-26.