Trans-cranial duplex and visfatin as markers for cerebrovascular complications in type 2 diabetes mellitus
Background and aims: Transcranial Doppler (TCD) is a modern and sophisticated diagnostic procedure that enables recording the changes in cerebral perfusion in various states. We aimed to look into the role of TCD in studying the cerebral changes that occur in type 2 diabetic patients, as well as their relationship to visfatin and macro-and microvascular complications. Material and method: Twenty diabetic patients with no vascular complications were placed in group1, twenty diabetic patients with macrovascular complications were placed in group2, and forty diabetic patients with microvascular complications were placed in group 3. Serum visfatin level and TCD were performed on all patients. Results: The pulsatile index of the right and left middle cerebral arteries (PI RT & LT MCA) have high sensitivity (69.2% and 64.1%, respectively) and specificity (75% and 95%) in predicting microvascular complications, with cut-off values of (1.005 and 1.035). A positive significant correlation between serum visfatin level and PI RT, and LT MCA with (p <0.001, =0.035 respectively) among diabetics with no complications group, (p<0.001) in both macro and micro-vascular complications group. Conclusion: TCD is a non-invasive technique for determining brain circulation and predicting complications and prognosis in high-risk diabetics.