ASSESSMENT OF NUTRITIONAL STATUS IN PATIENTS WITH METABOLIC SYNDROME AND CHRONIC HEPATITIS C
Background and Aims: The aim of the study was to assess nutritional status in patients with chronic hepatitis C and metabolic syndrome by different methods and to evaluate predictors of malnutrition. Material and Methods: This cross-sectional study was held in three centers from Bucharest and included 171 patients with chronic hepatitis C, divided into two groups according to the presence of metabolic syndrome (MetS). Anthropometric and biochemical parameters (including fasting plasma glucose, glycosylated hemoglobin, lipid profile, liver profile, complete blood count, and cytokines) were recorded. Nutritional status was assessed using Body Mass Index (BMI), Mini-nutritional assessment (MNA), Instant Nutritional Assessment (INA) and Nutritional Risk Index (NRI). We also recorded a malnutrition combined score. We considered patients to be malnourished according to the combined score if any score indicate malnutrition. Hepatic fibrosis was assessed using Forns index. Results: The average age was 53.14±8.3 years and 52% (n=89) were women. Using the combined score, malnutrition was present in 18 patients (10.5%). Multivariate logistic regression analysis showed that diabetes, hepatic fibrosis and IL-6 were independent risk factors for malnutrition (all p <0.05). Conclusions: Prevalence of malnutrition was high in patients with chronic hepatitis C (10.5%). In these patients diabetes, hepatic fibrosis and IL-6 were independent predictors for malnutrition.