Drug correction of endothelial dysfunction after operations for varicose veins

Volodumyr Goshschynsky; Bogdan Migenko; Roman Svistun; Liudmyla Migenko

Volodumyr Goshschynsky Department of Surgery, Faculty of Postgraduate Education, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Bogdan Migenko Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Roman Svistun Department of Surgery, Faculty of Postgraduate Education, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Liudmyla Migenko Department of Internal Medicine No.2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

Keywords: varicose veins, postoperative period, endothelial dysfunction, correction

Abstract

Endothelial dysfunction is one of the key points in the development of varicose veins in the lower extremities—the aim of the study. To determine the presence of endothelial dysfunction in the early and late postoperative period and to carry out its medical correction. Markers of endothelial dysfunction, in particular, P-selectin, E-selectin, tissue plasminogen activator, endothelin-1, vascular endothelial adhesion molecule type 1 and circulating endothelial cells were determined in patients with varicose veins operation. It has been established that indicators of endothelial dysfunction markers increase in the early postoperative period. After 60 days after surgical interventions, signs of endothelial dysfunction remain, although according to the analysis of indicators, it is lower than in the early postoperative period. At the same time, after analyzing the indicators obtained after the operation, we can conclude that using only diosmin with hesperidin reduces endothelial dysfunction in the early and late postoperative period but does not completely eliminate it. Combining diosmin with hesperidin and quercetin enhances their effect in the distant postoperative period, significantly reducing endothelial dysfunction indicators. After operations for varicose veins of the lower extremities, the manifestations of endothelial dysfunction persist, requiring medical correction. The combination of flavonoids diosmin + hesperidin + quercetin can be used to correct endothelial dysfunction in the early and late postoperative period.