Association of different vitamin D levels with metabolic syndrome components in type 2 diabetic patients in Gorgan

Karrar Jaber Hasan Al-hajmee; Safa Jalal Abdalsahib Alhasoon; Abdoljalal Marjani

Karrar Jaber Hasan Al-hajmee Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran
Safa Jalal Abdalsahib Alhasoon Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran
Abdoljalal Marjani Department of Biochemistry and Biophysics, Metabolic Disorders Research Center, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

Keywords: vitamin D, metabolic syndrome, components, type 2 diabetes

Abstract

This study was designed to evaluate and compare different levels of serum VD in MetS and T2DM subjects, and without MetS subjects, and to determine its association with MetS components in Gorgan. The study included 270 type 2 diabetic patients in 3 groups: Patients with MetS and VD deficiency Group 1), patients with MetS and a normal level of VD (Group 2) and patients without MetS and a normal level of VD (Group 3). The MetS criteria were defined using the National Cholesterol Education Program’s Adult Treatment Panel III guidelines. Waist circumference (WC), systolic and diastolic blood pressure (SBP, DBP), fasting blood sugar (FBS) and triglyceride (TG) were significantly higher, and High-density lipoprotein cholesterol (HDL-C) and VD levels were significantly lower in Groups 1 and 2 than in Group 3. FBS and TG levels were significantly higher, and VD levels were significantly lower in Group 1 than in Group 3. Negative correlations exist between VD, FBS, and TG in group 1. Vitamin D deficiency may increase the risk of Mets. The relationship between VD deficiency and an increase in FBS and TG levels suggests that subjects in this group should manage their FBS and TG levels.