THE RELATIONSHIP BETWEEN LIPID METABOLISM AND THE LEVEL OF ALBUMINURIA WITH SINGLE NUCLEOTIDE POLYMORPHISM - 204A>C [RS 3808607] CYP7A1 GENE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND DIABETIC NEPHROPATHY

  • Nadiia Demikhova Sumy State University
  • Cherkashyna Lidiya
  • Olha Chernatska
  • Tetyana Mazur
  • Tetyana Aleksakhina
  • Oleksii Demikhov
Keywords: type 2 diabetes mellitus, albuminuria, diabetic nephropathy, СYP7A1 gene

Abstract

Background and aims. The purpose of our study was to determine the features of diabetic nephropathy, to identify the relationship between the level of albumin excretion, urine and lipid profile, genotype variants of the CYP7A1 gene in people with type 2 diabetes and diabetic nephropathy. Material and methods. Patients were divided into three groups. Normoalbinuria was detected in group I, and II - microalbuminuria, and III - macroalbuminuria. Determination of albumin to creatinine ratio was more accurate, although more expensive method. We examined single nucleotide polymorphism -204A> C [rs 3808607] of the promoter region of the CYP7A1 gene. Results. It was established that homozygotes by the major allele with genotype AA had lower values of albuminuria, atherogenic lipoproteins, total cholesterol, triglycerides and higher levels of anti- atherogenic lipoproteins than patients with AС and СС genotypes. Conclusion. The ССgenotype was most unfavorable in the prognostic plan, since homozygotes for this minor allele were characterized by higher values of albuminuria, total cholesterol, triglycerides, and lower values of high-density lipoprotein

Published
2019-10-22
How to Cite
Demikhova, Nadiia, Cherkashyna Lidiya, Olha Chernatska, Tetyana Mazur, Tetyana Aleksakhina, and Oleksii Demikhov. 2019. “THE RELATIONSHIP BETWEEN LIPID METABOLISM AND THE LEVEL OF ALBUMINURIA WITH SINGLE NUCLEOTIDE POLYMORPHISM - 204A>C [RS 3808607] CYP7A1 GENE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND DIABETIC NEPHROPATHY”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (3), 253-61. http://rjdnmd.org/index.php/RJDNMD/article/view/627.
Section
Original Research Articles