EARLY RENAL DYSFUNCTION IN OBESE PATIENTS WITH INSULIN RESISTANCE

  • Natalia Pertseva
  • Mariia Rokutova endocrinologist
Keywords: insulin resistance, obesity, HOMA-IR index, glomerular filtration rate, β2-microglobulinuria

Abstract

Background and aims: Obese individuals have insulin resistance status assessed in the present study by the HOMA index ("Homeostasis model assessment"). This prospective study assessed renal disorders in the insulin resistance in obese patients. Material and Methods: The study included 73 young obese patients. The assessment included  the HOMA index before meal and parameters of renal function (glomerular filtration rate, albuminuria, β2-microglobulinuria). Results: In young obese, insulin-resistance patients, glomerular hyperfiltration and β2-microglobulinuria are found in 77.0 and 93.4% of cases respectively. The albuminuria is noted in some cases, which reduces diagnostic value. Conclusions: In young obese patients with insulin resistance, glomerular hyperfiltration and β2-microglobulinuria are main diagnostic markers of renal dysfunction.

Published
2019-10-22
How to Cite
Pertseva, Natalia, and Mariia Rokutova. 2019. “EARLY RENAL DYSFUNCTION IN OBESE PATIENTS WITH INSULIN RESISTANCE”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (3), 261-65. http://rjdnmd.org/index.php/RJDNMD/article/view/630.
Section
Original Research Articles