BENEFICIAL EFFECT OF PACHYRHIZUS EROSUS FIBER AS A SUPPLEMENTAL DIET TO COUNTERACT HIGH SUGAR-INDUCED FATTY LIVER DISEASE IN MICE

  • Putra Santoso Biology Department Faculty of Mathematics and Natural Sciences Andalas Universitys
  • Rita Maliza
  • Qonitah Fadhilah
  • Siti Jamalul Insani
Keywords: edible fiber, diabetes, obesity, NAFLD, hepatolysis

Abstract

Background and aims: Edible fiber isolated from the tuber of yam bean (Pachyrhizus erosus, Leguminosae) has been suggested to prevent the development of metabolic diseases caused by excessively consuming sugary foods. However, it is unclarified whether P. erosus fiber (PEF) is also capable of preventing liver diseases. This study aimed to determine the effectivity of PEF in counteracting the development of non-alcoholic fatty liver disease (NAFLD) caused by excessive intake of high-sugar diet (HSD). Material and method: 25% of PEF in HSD (w/w) was fed in BALB/c mice for eight weeks followed by subsequent morphological and histological examinations of the liver at the end of treatment in comparing with HSD alone. Results: We found that supplementation of 25% PEF sustained the normal morphological feature of the liver in HSD-fed mice. Moreover, PEF also prevented the development of microvesicles in the liver tissue, nuclear shrinkage, and hepatolysis as indicators of liver disease. Macrophages infiltration as a marker of liver inflammation was also less observed in PEF-treated mice. Conclusions: PEF could effectively elicit a beneficial effect against NAFLD caused by HSD. Hence, PEF is suggested to be used as a potent supplemental diet to preclude the metabolic diseases caused by HSD.

Published
2020-02-01
How to Cite
Santoso, Putra, Rita Maliza, Qonitah Fadhilah, and Siti Insani. 2020. “BENEFICIAL EFFECT OF PACHYRHIZUS EROSUS FIBER AS A SUPPLEMENTAL DIET TO COUNTERACT HIGH SUGAR-INDUCED FATTY LIVER DISEASE IN MICE”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (4), 353-60. http://rjdnmd.org/index.php/RJDNMD/article/view/647.
Section
Original Research Articles