The Relationship of Mean Platelet Volume and Atherogenic Index of Plasma with Atherothrombotic Cardiovascular Disease in Diabetes

  • Usama Ragab internal medicine department, faculty of medicine, Zagazig university, Zagazig, Egypt
  • Fayrouz Othman Selim, Dr Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
  • Ahmed Ibrahim El-Agroody, Dr Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt http://orcid.org/0000-0003-2155-9113
  • Mohamed Hossam Eldin Mourad, Prof Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
  • Mohamed Mohamed Sakr, Prof Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Keywords: atherothrombosis, diabetes mellitus, inflammation, platelets

Abstract

 

 

 

 Introduction: Atherothrombotic cardiovascular disease is the major cause of disability and death in diabetic patients. Dys­lipidemia and inflammation play a major role in the pathogenesis of atherothrombotic cardiovascular disease in diabetic pa­tients. We aimed to assess the association between platelet volume and the atherogenic index of plasma in relation to athero­thrombotic cardiovascular disease in diabetes. Material and Methods: In 108 diabetic patients, which were divided into two groups according to the atherothrombotic cardiovascular disease, we assessed the mean platelet volume and the atherogenic index of plasma. In diabetic patients without atherothrombotic cardiovascular disease, we calculated the Framingham risk score, which was then correlated with the mean platelet volume and atherogenic index of plasma. Results: The mean platelet volume and atherogenic index of plasma were significantly higher in diabetic patients with atherothrombotic cardiovascu­lar disease. Also, both were increased in diabetic patients with a high calculated Framingham risk score compared to other groups. There was a statistically significant positive correlation between atherogenic index of plasma, mean platelet volume, and Framingham risk score (n= 54, r = 0.595, P < 0.0001 and r = 0.473, P = 0.0003). Conclusions: This study concluded that the mean platelet volume and the atherogenic index of plasma are increased in diabetic patients with atherothrombotic cardio­vascular disease. Also, they were increased in diabetic patients with higher Framingham risk score and this may confer future risk for atherothrombotic cardiovascular events.

Published
2020-08-13
How to Cite
Ragab, Usama, Fayrouz Selim, Ahmed El-Agroody, Mohamed Mourad, and Mohamed Sakr. 2020. “The Relationship of Mean Platelet Volume and Atherogenic Index of Plasma With Atherothrombotic Cardiovascular Disease in Diabetes”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 27 (2), 112-19. http://rjdnmd.org/index.php/RJDNMD/article/view/713.
Section
Original Research Articles