A prominent action of Insulin like growth factor I (IGF-I) in stimulation of uterine leiomyomata: a review

  • Israa Yousef Department of biological sciences, School of Science, the University of Jordan, Amman, Jordan
  • Moath Alqaraleh Department of Biology Sciences, faculty of Science. The University of Jordan, Amman, Jordan
Keywords: Uterine leiomyomata, Insulin like growth factor I (IGF-I), estrogen, and progestron.


Uterine leiomyomata is a common disease of the female reproductive system. It causes many complications, such as heavy bleeding and menorrhagia. However, the causes of uterine leiomyomata are still unclear. Studies have shown that estrogen, progesterone, and insulin-like growth factor I play key roles in the development of uterine leiomyomata. Abnormal expression of insulin-like growth factor I is believed to be one of the factors that lead to uterine leiomyomata. Uterine leiomyomata are con­sidered benign tumors, which do not lose division control like malignant cells. There are many factors involved in the pathways of uterine leiomyomata onset, such as various growth factors, cytokines, and steroid hormones.

How to Cite
Yousef, Israa, and Moath Alqaraleh. 2020. “A Prominent Action of Insulin Like Growth Factor I (IGF-I) in Stimulation of Uterine Leiomyomata: A Review”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 27 (2), 162-67. http://rjdnmd.org/index.php/RJDNMD/article/view/714.
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