Dynamics of antioxidant status and nitrogen oxide systems in rats with metabolic syndrome after bariatric surgeries
Background and aims: Metabolic syndrome still requires the development of new treatments. The aim of the study was to study the state of the nitric oxide system, lipid peroxidation and antioxidant system in the body of animals with metabolic syndrome, which has received surgical treatment of obesity by different methods. Material and methods: The studies were performed on 40 white male Wistar rats. Male rats of the main group (n = 8) were fed a high-fat diet (HFD) for 16 weeks, thus simulating the development of MS. After exposure to a high-fat diet for 16 weeks, rats in the HFD cohort were randomly assigned to non-surgical HFDs and HFDs who underwent appropriate surgery intervention. Results: Surgical treatment of obesity reduces the intensity of lipid peroxidation, nitrooxidative stress and improves antioxidant defense mechanisms in all studied groups of animals with simulated metabolic syndrome. However, only in the group of rats that underwent left gastric artery ligation surgery, the improvement of the pro- and anti-oxidant (the level of superoxide dismutase increased in 1.52 times; p <0.05) system and the nitric oxide system (the level of NO-synthase decreased in 41.17%; p <0.05) was statistically significant for all studied indicators.