Study to find out the role of neutrophil lymphocyte ratio and platelet lymphocyte ratio as diagnostic biomarkers for gestational diabetes mellitus – A cross-sectional study

Abstract

Introduction: Gestational diabetes mellitus (GDM) is a condition leading to the development of glucose intolerance for the first time in pregnancy. Early detection of this condition can prevent the morbidity and mortality of women with GDM. Aim: To find out the role of NLR ratio and PLR ratio as a diagnostic marker in the development of GDM. Materials and methods: It was a cross-sectional study done among patients attending Chettinad Hospital and Research Institute among 156 pregnant women. They were divided into two groups based on the OGTT 2 hour values into post glucose values into those with values >140 mg/dl (60) and those with values <140 mg/dl (96). HbA1c, post glucose values total blood count, platelet count, RBC count, PCV, neutrophils,
lymphocytes, eosinophils, basophils, lymphocytes, and monocytes were measured among all the patients. Results: Mean and SD were calculated for all the variables. An independent sample t-test was done between the groups. Post glucose, TLC (total leucocyte count) MCV (mean corpuscular volume), MCHC (mean corpuscular hemoglobin concentration), NLR ratio and PLR ratio showed a significant differences between the two groups. Conclusion: There was a significant difference in the levels of NLR ratio and PLR ratio between GDM women and normal pregnant women. These parameters can be used as a diagnostic tool for GDM.